Comparison of Downstream Processing of Nanocrystalline Solid Dispersion and Nanosuspension of Diclofenac Acid to Develop Solid Oral Dosage Form.

ABSTRACT: The conventional "top-down", "bottom-up" and "combination" approaches of generating drug nanocrystals produce a "nanosuspension" (NS). It requires significant downstream processing for drying the liquid by suitable means followed by its granulation to develop an oral solid dosage form (OSD). In this paper, we used a novel, spray drying-based NanoCrySP technology for the generation of drug nanocrystals in the form of nanocrystalline solid dispersion (NCSD). We hypothesized that the NCSD would require minimal downstream processing since the nanocrystals are obtained in powder form during spray drying. We further compared downstream processing of NS and NCSD of diclofenac acid (DCF) prepared by wet media milling and NanoCrySP technology, respectively. The NS and NCSD were characterized for cr

SUBMITTER: Jadhav S 

PROVIDER: S-EPMC7690810 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature