Identifying Candidate Genetic Markers of CDV Cross-Species Pathogenicity in African Lions.

ABSTRACT: Canine distemper virus (CDV) is a multi-host pathogen with variable clinical outcomes of infection across and within species. We used whole-genome sequencing (WGS) to search for viral markers correlated with clinical distemper in African lions. To identify candidate markers, we first documented single-nucleotide polymorphisms (SNPs) differentiating CDV strains associated with different clinical outcomes in lions in East Africa. We then conducted evolutionary analyses on WGS from all global CDV lineages to identify loci subject to selection. SNPs that both differentiated East African strains and were under selection were mapped to a phylogenetic tree representing global CDV diversity to assess if candidate markers correlated with documented outbreaks of clinical distemper in lions (n

SUBMITTER: Weckworth JK 

PROVIDER: S-EPMC7690837 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature