Nuclear Isoforms of Neurofibromin Are Required for Proper Spindle Organization and Chromosome Segregation.

ABSTRACT: Mitotic spindles are highly organized, microtubule (MT)-based, transient structures that serve the fundamental function of unerring chromosome segregation during cell division and thus of genomic stability during tissue morphogenesis and homeostasis. Hence, a multitude of MT-associated proteins (MAPs) regulates the dynamic assembly of MTs in preparation for mitosis. Some tumor suppressors, normally functioning to prevent tumor development, have now emerged as significant MAPs. Among those, neurofibromin, the product of the Neurofibromatosis-1 gene (NF1), a major Ras GTPase activating protein (RasGAP) in neural cells, controls also the critical function of chromosome congression in astrocytic cellular contexts. Cell type- and development-regulated splicings may lead to the inclusion

SUBMITTER: Peta C 

PROVIDER: S-EPMC7690890 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature