Design and Characterization of Glyceryl Monooleate-Nanostructures Containing Doxorubicin Hydrochloride.

ABSTRACT: Glyceryl monooleate (GMO) is one of the most popular amphiphilic lipids, which, in the presence of different amounts of water and a proper amount of stabilizer, can promote the development of well defined, thermodynamically stable nanostructures, called lyotropic liquid crystal dispersions. The aim of this study is based on the design, characterization, and evaluation of the cytotoxicity of lyotropic liquid crystal nanostructures containing a model anticancer drug such as doxorubicin hydrochloride. The drug is efficiently retained by the GMO nanosystems by a remote loading approach. The nanostructures prepared with different non-ionic surfactants (poloxamers and polysorbates) are characterized by different physico-chemical features as a function of several parameters, i.e., serum stability

SUBMITTER: Gagliardi A 

PROVIDER: S-EPMC7690907 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature