Ontology highlight
ABSTRACT:
SUBMITTER: Kuribayashi W
PROVIDER: S-EPMC7690939 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Kuribayashi Wakako W Oshima Motohiko M Itokawa Naoki N Koide Shuhei S Nakajima-Takagi Yaeko Y Yamashita Masayuki M Yamazaki Satoshi S Rahmutulla Bahityar B Miura Fumihito F Ito Takashi T Kaneda Atsushi A Iwama Atsushi A
The Journal of experimental medicine 20210301 3
Hematopoietic stem cells (HSCs) exhibit functional alterations, such as reduced regenerative capacity and myeloid-biased differentiation, with age. The HSC niche, which is essential for the maintenance of HSCs, also undergoes marked changes with aging. However, it has been technically challenging to directly evaluate the contribution of niche aging to age-associated HSC alterations without niche-damaging myeloablation in HSC transplantation assays. We herein transplanted an excess of aged HSCs i ...[more]