Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards.

ABSTRACT: Antimicrobial resistance (AMR) is a global threat. A better understanding of how antibiotic use and between-ward patient transfers (or connectivity) impact population-level AMR in hospital networks can help optimize antibiotic stewardship and infection control strategies. Here, we used a metapopulation framework to explain variations in the incidence of infections caused by seven major bacterial species and their drug-resistant variants in a network of 357 hospital wards. We found that ward-level antibiotic consumption volume had a stronger influence on the incidence of the more resistant pathogens, while connectivity had the most influence on hospital-endemic species and carbapenem-resistant pathogens. Piperacillin-tazobactam consumption was the strongest predictor of the cumulative incid

SUBMITTER: Shapiro JT 

PROVIDER: S-EPMC7690951 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature