Toluidine blue versus frozen section for assessment of mucosal tumor margins in oral squamous cell carcinoma.

ABSTRACT:

Background

When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sampling error. This study evaluated the effectiveness of using toluidine blue (TB) as an intraoperative triage screening tool to detect positive mucosal margins of the resected specimens of oral squamous cell carcinoma (OSCC) and serve as a guide for FS sampling.

Methods

Surgical samples of 30 consecutive patients with biopsy-proven OSCC were included in the study. A total of 140 mucosal margins were analyzed intraoperatively by TB and FS, the results were compared with the final histopathology.

Results

Of the 140 examined mucosal tumor margins, 14 stai

SUBMITTER: Algadi HH 

PROVIDER: S-EPMC7691066 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature