Impact of homologous recombination on core genome phylogenies.

ABSTRACT:

Background

Core genome phylogenies are widely used to build the evolutionary history of individual prokaryote species. By using hundreds or thousands of shared genes, these approaches are the gold standard to reconstruct the relationships of large sets of strains. However, there is growing evidence that bacterial strains exchange DNA through homologous recombination at rates that vary widely across prokaryote species, indicating that core genome phylogenies might not be able to reconstruct true phylogenies when recombination rate is high. Few attempts have been made to evaluate the robustness of core genome phylogenies to recombination, but some analyses suggest that reconstructed trees are not always accurate.

Results

In this study, we tested the robustness of core genome p

SUBMITTER: Stott CM 

PROVIDER: S-EPMC7691112 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature