SSRI Treatment Response Prediction in Depression Based on Brain Activation by Emotional Stimuli.

ABSTRACT: Introduction: The prediction of antidepressant treatment response may improve outcome. Functional magnetic resonance imaging (fMRI) of emotion processing in major depressive disorder (MDD) may reveal regional brain function serving as predictors of response to treatment with selective serotonin reuptake inhibitor (SSRI). Methods: We examined the association between pre-treatment neural activity by means of fMRI during the perception of emotional stimuli in 22 patients with MDD and the treatment outcome after 6 weeks' medication with an SSRI. A whole brain correlation analysis with Beck Depression Inventory (BDI) change between pre- to post-treatment was conducted to identify neural regions associated with treatment response. Results: During the perception of positive s

SUBMITTER: Preuss A 

PROVIDER: S-EPMC7691246 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature