Emergence of a Clinical Escherichia coli Sequence Type 131 Strain Carrying a Chromosomal bla _KPC-2 Gene.

ABSTRACT: Objectives: Bacteria carrying the Klebsiella pneumoniae carbapenemase genes have rapidly spread worldwide and have become a great threat to public health. The bla _KPC-2 gene has been primarily located on plasmids cocirculating in various strains. However, chromosomal integration of the bla _{KPC -2} gene in Escherichia coli has not been reported. In the present study, we report the detection of the first clinical strain of E. coli ST131 with a bla _{KPC -2} gene, which integrated in the chromosome. E. coli strain EC3385 was identified and subjected to susceptibility testing and genotyping. The complete genome sequences of this strain and four Proteus mirabilis

SUBMITTER: Wang D 

PROVIDER: S-EPMC7691318 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature