Interindividual Variability of Lower-Limb Motor Cortical Plasticity Induced by Theta Burst Stimulation.

ABSTRACT: Theta burst stimulation (TBS) has been used as a tool to induce synaptic plasticity and improve neurological disorders. However, there is high interindividual variability in the magnitude of the plastic changes observed after TBS, which hinders its clinical applications. The electric field induced by transcranial magnetic stimulation (TMS) is strongly affected by the depth of the stimulated brain region. Therefore, it is possible that the variability in the response to TBS over the lower-limb motor cortex is different for the hand area. This study investigated the variability of TBS-induced synaptic plasticity in the lower-limb motor cortex, for intermittent TBS (iTBS), continuous TBS (cTBS), and sham iTBS, in 48 healthy young participants. The motor cortical and intracortical excitability

SUBMITTER: Katagiri N 

PROVIDER: S-EPMC7691321 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature