Systematic Review: Monoclonal Antibody-Induced Subacute Cutaneous Lupus Erythematosus.

ABSTRACT:

Background

Subacute cutaneous lupus erythematosus (SCLE) lacks consensus diagnostic criteria and the pathogenesis is poorly understood. There are increasing reports of SCLE induced by monoclonal antibodies (mAbs), but there are limited data on the aetiology, clinical characteristics and natural course of this disease.

Methods

We devised a set of diagnostic criteria for SCLE in collaboration with a multinational, multispecialty panel. This systematic review employed a two-layered search strategy of five databases for cases of mAb-induced SCLE (PROSPERO registered protocol CRD42019116521). To explore the relationship between relative mAb use and the number of SCLE cases reported, the estimated number of mAb users was modelled from 2013 to 2018 global commercial data and estima

SUBMITTER: Bolton C 

PROVIDER: S-EPMC7691410 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature