Cardiovascular disease risk and the time to insulin initiation for Medicaid enrollees with type 2 diabetes.

ABSTRACT:

Aims

We evaluated the relationship between the timing of insulin initiation and cardiovascular diseases (CVD) risk in Pennsylvania Medicaid enrollees with type 2 diabetes (T2D).

Methods

We included 17,873 enrollees (age 47.4 ± 10.3 years; range 18-64 years) initially treated with non-insulin glucose-lowering agents (GLAs) in 2008-2016. Based on clinical guidelines, we identified early (N = 1,158; 6%; insulin initiation ≤ 6 months after first-line GLAs), in-time (N = 569; 3%; 6-12 months), delayed (N = 2,761; 15%; >12 months), and non-insulin users (N = 13,385; 75%). The Prentice-Williams-Peterson (PWP) models with inverse probability weighting estimated CVD risk across the four groups and the change in risk after insulin initiation.

Results

Regardless of time to insul

SUBMITTER: Xue L 

PROVIDER: S-EPMC7691549 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature