Gene expression profiling of corona virus microarray datasets to identify crucial targets in COVID-19 patients.

ABSTRACT: The current outbreak of coronavirus disease (COVID-19) has been affecting millions of people and has caused devastating mortality worldwide. Moreover, it is to be noted that cytokine storm has become an important cause for the rising mortality. However, the efforts for the development of drugs, vaccines and treatment has also been intervened due to poor understanding of host's defense mechanism and also due to the development of cytokine storm against this viral infection. Thus, a deeper understanding of the mechanism behind the immune dysregulation and cytokine storm development might give us clues for the clinical management of the severe cases. Hence, we have implemented differential gene expression analysis together with protein-protein interaction and Gene Ontology (GO) studies with t

SUBMITTER: Ramesh P 

PROVIDER: S-EPMC7691848 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature