A comparison of vaginal versus buccal misoprostol for cervical ripening in women for labor induction at term (the IMPROVE trial): a triple-masked randomized controlled trial.

ABSTRACT:

Background

Cervical ripening is commonly needed for labor induction. Finding an optimal route of misoprostol dosing for efficacy, safety, and patient satisfaction is important and not well studied for the buccal route.

Objective

To compare the efficacy and safety of vaginal and buccal misoprostol for women undergoing labor induction at term.

Study design

The IMPROVE trial was an institutional review board-approved, triple-masked, placebo-controlled randomized noninferiority trial for women undergoing labor induction at term with a Bishop score ≤6. Enrolled women received 25 mcg (first dose), then 50 mcg (subsequent doses) of misoprostol by assigned route (vaginal or buccal) and a matching placebo tablet by the opposite route. The primary outcomes were time to delivery

SUBMITTER: Haas DM 

PROVIDER: S-EPMC7692024 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature