NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences.

ABSTRACT: Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically dis-ordered regions. These segments are involved in binding to partner molecules, such as protein and DNA, and play important roles in signaling pathways and/or transcriptional regulation. Although there are databases that gather information on such disordered binding regions, data remain limited. Therefore, it is desirable to develop programs to predict the disordered binding regions without using data for the binding regions. We developed a program, NeProc, to predict the disordered binding regions, which can be regarded as intrinsically disordered regions with a structur

SUBMITTER: Anbo H 

PROVIDER: S-EPMC7692026 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature