Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives.

ABSTRACT: Metabolic reprogramming contributes to the pathogenesis and heterogeneity of melanoma. It is driven both by oncogenic events and the constraints imposed by a nutrient- and oxygen-scarce microenvironment. Among the most prominent metabolic reprogramming features is an increased rate of lipid synthesis. Lipids serve as a source of energy and form the structural foundation of all membranes, but have also emerged as mediators that not only impact classical oncogenic signaling pathways, but also contribute to melanoma progression. Various alterations in fatty acid metabolism have been reported and can contribute to melanoma cell aggressiveness. Elevated expression of the key lipogenic fatty acid synthase is associated with tumor cell invasion and poor prognosis. Fatty acid uptake from the surro

SUBMITTER: Pellerin L 

PROVIDER: S-EPMC7692067 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature