Prolonged Effect of Seminal Plasma on Global Gene Expression in Porcine Endometrium.

ABSTRACT: Seminal plasma (SP) deposited in the porcine uterine tract at the time of mating is known to elicit an initial response that is beneficial for pregnancy outcome. However, whether SP has any long-term effect on alterations in endometrial molecular and cellular processes is not known. In this study, using microarray analyses, differential changes in endometrial transcriptome were evaluated after Day 6 of SP-infusion (6DPI) or Day 6 of pregnancy as compared to corresponding day of estrous cycle. Both, pregnancy and SP induced significant changes in the endometrial transcriptome and most of these changes were specific for a particular group. Functional analysis of differentially expressed genes (DEGs) using Ingenuity Pathway Analysis revealed that inhibition in immune response was affected by

SUBMITTER: Bogacki M 

PROVIDER: S-EPMC7692128 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature