Expanding the Geographic Characterisation of Epstein-Barr Virus Variation through Gene-Based Approaches.

ABSTRACT: The Epstein-Barr Virus (EBV) infects the vast majority of human individuals worldwide (~90%) and is associated with several diseases, including different types of cancer and multiple sclerosis, which show wide variation in incidence among global geographical regions. Genetic variants in EBV genomic sequences have been used to determine the geographical structure of EBV isolates, but our understanding of EBV diversity remains highly incomplete. We generated sequences for 13 pivotal EBV genes derived from 103 healthy individuals, expanding current EBV diversity datasets with respect to both geographic coverage and number of isolates per region. These newly generated sequences were integrated with the more than 250 published EBV genomes, generating the most geographically comprehensive data s

SUBMITTER: Telford M 

PROVIDER: S-EPMC7692309 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature