Regulation of Canonical Oncogenic Signaling Pathways in Cancer via DNA Methylation.

ABSTRACT: Disruption of signaling pathways that plays a role in the normal development and cellular homeostasis may lead to the dysregulation of cellular signaling and bring about the onset of different diseases, including cancer. In addition to genetic aberrations, DNA methylation also acts as an epigenetic modifier to drive the onset and progression of cancer by mediating the reversible transcription of related genes. Although the role of DNA methylation as an alternative driver of carcinogenesis has been well-established, the global effects of DNA methylation on oncogenic signaling pathways and the presentation of cancer is only emerging. In this article, we introduced a differential methylation parsing pipeline (MethylMine) which mined for epigenetic biomarkers based on feature selection. This p

SUBMITTER: Lu J 

PROVIDER: S-EPMC7692324 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature