A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer.

ABSTRACT: The Notch signal transduction pathway is pivotal for various physiological processes, including immune responses, and has been implicated in the pathogenesis of many diseases. The effectiveness of various targeted Notch pathway inhibitors may vary due to variabilities in Notch pathway activity among individual patients. The quantitative measurement of Notch pathway activity is therefore essential to identify patients who could benefit from targeted treatment. We here describe a new assay that infers a quantitative Notch pathway activity score from the mRNA levels of generally conserved direct NOTCH target genes. Following the calibration and biological validation of our Notch pathway activity model over a wide spectrum of human cancer types, we assessed Notch pathway activity in a cohort o

SUBMITTER: Cante-Barrett K 

PROVIDER: S-EPMC7692325 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature