PARPBP is a prognostic marker and confers anthracycline resistance to breast cancer.

ABSTRACT:

Background

PARPBP (PARP1 binding protein) is an important suppressor of homologous recombination during DNA repair, but the expression and function of PARPBP in breast cancer remain unclear.

Methods

PARPBP expression was analyzed in breast cancer patient samples and public datasets for its correlation with clinical outcome. The function of PARPBP in breast cancer cell proliferation and anthracycline treatment response were studied both in vitro and in vivo.

Results

PARPBP was upregulated significantly at both mRNA and protein levels in breast cancer tissues compared with normal breast tissues. PARPBP high expression group had poorer overall survival (OS) than the PARPBP low expression group. Knockdown of PARPBP suppressed breast cancer cell proliferation

SUBMITTER: Chen B 

PROVIDER: S-EPMC7692344 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature