Patient-Derived Papillary Thyroid Cancer Organoids for Radioactive Iodine Refractory Screening.

ABSTRACT: Patients with well-differentiated thyroid cancer, especially papillary thyroid cancer (PTC), are treated with surgical resection of the thyroid gland. This is followed by post-operative radioactive iodine (I131), resulting in total thyroid ablation. Unfortunately, about 15-33% of PTC patients are unable to take up I131, limiting further treatment options. The aim of our study was to develop a cancer organoid model with the potential for pre-treatment diagnosis of these I131-resistant patients. PTC tissue from thirteen patients was used to establish a long-term organoid model. These organoids showed a self-renewal potential for at least five passages, suggesting the presence of cancer stem cells. We demonstrated that thyroid specific markers, a PTC marker, and transporters/receptors necessa

SUBMITTER: Sondorp LHJ 

PROVIDER: S-EPMC7692469 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature