Protective effect of influenza vaccination on cardiovascular diseases: a systematic review and meta-analysis.

ABSTRACT: Cardiovascular diseases (CVDs) are among the leading causes of mortality and morbidity worldwide. There are many contrasting ideas on the effectiveness of influenza vaccination on CVDs. This study aimed to investigate the association between influenza vaccination and the risk of CVDs. We systematically searched all PubMed/Medline, EMBASE, and the Cochrane library entries up to November 2019 for studies of influenza vs. the CVDs outcomes. We conducted a random-effects meta-analysis using the inverse variance method for pooled risk ratios (RR) or odds ratios (OR) and evaluated statistical heterogeneity using the I² statistic. We identified 17 studies (6 randomized controlled trial [RCT], 5 cohorts, and 6 case-control) with a total of 180,043 cases and 276,898 control participants.

SUBMITTER: Zangiabadian M 

PROVIDER: S-EPMC7692477 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature