Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension.

ABSTRACT: A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H₂) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H₂ has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H₂ (1.3% H₂ + 21% O₂ + 77.7% N₂) or control (21% O₂ + 79% N₂) gas mixture for 1 h per day. H₂ significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H₂ was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H₂ on hypertension, we used an implanted teleme

SUBMITTER: Sugai K 

PROVIDER: S-EPMC7692487 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature