CancerGram: An Effective Classifier for Differentiating Anticancer from Antimicrobial Peptides.

ABSTRACT: Antimicrobial peptides (AMPs) constitute a diverse group of bioactive molecules that provide multicellular organisms with protection against microorganisms, and microorganisms with weaponry for competition. Some AMPs can target cancer cells; thus, they are called anticancer peptides (ACPs). Due to their small size, positive charge, hydrophobicity and amphipathicity, AMPs and ACPs interact with negatively charged components of biological membranes. AMPs preferentially permeabilize microbial membranes, but ACPs additionally target mitochondrial and plasma membranes of cancer cells. The preference towards mitochondrial membranes is explained by their membrane potential, membrane composition resulting from α-proteobacterial origin and the fact that mitochondrial targeting signals could have ev

SUBMITTER: Burdukiewicz M 

PROVIDER: S-EPMC7692641 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature