Cross-Linking Optimization for Electrospun Gelatin: Challenge of Preserving Fiber Topography.

ABSTRACT: Opportunely arranged micro/nano-scaled fibers represent an extremely attractive architecture for tissue engineering, as they offer an intrinsically porous structure, a high available surface, and an ideal microtopography for guiding cell migration. When fibers are made with naturally occurring polymers, matrices that closely mimic the architecture of the native extra-cellular matrix and offer specific chemical cues can be obtained. Along this track, electrospinning of collagen or gelatin is a typical and effective combination to easily prepare fibrous scaffolds with excellent properties in terms of biocompatibility and biomimicry, but an appropriate cross-linking strategy is required. Many common protocols involve the use of swelling solvents and can result in significant impairment of fib

SUBMITTER: Campiglio CE 

PROVIDER: S-EPMC7692762 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature