Stressful life events are associated with the risk of multiple sclerosis.

ABSTRACT:

Background and purpose

Unexpected stressful life events may alter immune function and affect susceptibility to autoimmune diseases including multiple sclerosis (MS). Current results from epidemiological investigations examining the role of stress in MS remain inconsistent. The aim was to conduct the hitherto largest population-based case-control study on this topic.

Methods

Extensive questionnaire information collected on lifestyle environmental factors available for 2930 incident MS cases and 6170 controls were used to assess the association of 10 major life events that had occurred before disease onset with the risk of MS by unconditional logistic regressions, adjusting for potential confounders. Stratified analyses were also performed by sex and time.

Results

Compe

SUBMITTER: Jiang X 

PROVIDER: S-EPMC7692913 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature