Ontology highlight
ABSTRACT:
SUBMITTER: Ha NT
PROVIDER: S-EPMC7693003 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Ha Nguyen Thi NT Lee Chang Hoon CH
Cells 20201025 11
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of ...[more]