Increasing Prevalence of HIV-1 Transmitted Drug Resistance in Portugal: Implications for First Line Treatment Recommendations.

ABSTRACT:

Introduction

Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug resistance (ADR).

Objective

To study the trends of TDR and ADR in patients followed up in Portuguese hospitals between 2001 and 2017.

Methods

In total, 11,911 patients of the Portuguese REGA database were included. TDR was defined as the presence of one or more surveillance drug resistance mutation according to the WHO surveillance list. Genotypic resistance to ARV was evaluated with Stanford HIVdb v7.0. Patterns of TDR, ADR and the prevalence of mutations over time were analyzed using logistic regression.

Results and

SUBMITTER: Pingarilho M 

PROVIDER: S-EPMC7693025 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature