Comparison of chitin-induced natural transformation in pandemic Vibrio cholerae O1 El Tor strains.

ABSTRACT: The human pathogen Vibrio cholerae serves as a model organism for many important processes ranging from pathogenesis to natural transformation, which has been extensively studied in this bacterium. Previous work has deciphered important regulatory circuits involved in natural competence induction as well as mechanistic details related to its DNA acquisition and uptake potential. However, since competence was first reported for V. cholerae in 2005, many researchers have struggled with reproducibility in certain strains. In this study, we therefore compare prominent seventh pandemic V. cholerae isolates, namely strains A1552, N16961, C6706, C6709, E7946, P27459, and the close relative MO10, for their natural transformability and decipher underlying defects that mask the high degree of compet

SUBMITTER: Stutzmann S 

PROVIDER: S-EPMC7693049 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature