Spatial patterns of correlation between cortical amyloid and cortical thickness in a tertiary clinical population with memory deficit.

ABSTRACT: To estimate regional Alzheimer disease (AD) pathology burden clinically, analysis methods that enable tracking brain amyloid or tau positron emission tomography (PET) with magnetic resonance imaging (MRI) measures are needed. We therefore developed a robust MRI analysis method to identify brain regions that correlate linearly with regional amyloid burden in congruent PET images. This method was designed to reduce data variance and improve the sensitivity of the detection of cortical thickness-amyloid correlation by using whole brain modeling, nonlinear image coregistration, and partial volume correction. Using this method, a cross-sectional analysis of 75 tertiary memory clinic AD patients was performed to test our hypothesis that regional amyloid burden and cortical thickness are inversel

SUBMITTER: Pillai JA 

PROVIDER: S-EPMC7693188 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature