Blockade of Glial Connexin 43 Hemichannels Reduces Food Intake.

ABSTRACT: The metabolic syndrome, which comprises obesity and diabetes, is a major public health problem and the awareness of energy homeostasis control remains an important worldwide issue. The energy balance is finely regulated by the central nervous system (CNS), notably through neuronal networks, located in the hypothalamus and the dorsal vagal complex (DVC), which integrate nutritional, humoral and nervous information from the periphery. The glial cells' contribution to these processes emerged few year ago. However, its underlying mechanism remains unclear. Glial connexin 43 hemichannels (Cx43 HCs) enable direct exchange with the extracellular space and can regulate neuronal network activity. In the present study, we sought to determine the possible involvement of glial Cx43 HCs in energy balan

SUBMITTER: Guillebaud F 

PROVIDER: S-EPMC7693394 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature