How Do You Feel Now? The Salience Network Functional Connectivity in End-Stage Renal Disease.

ABSTRACT:

Objective

The network connectivity basis of cognitive declines in end-stage renal disease (ESRD) remains unclear. A triple-network model of the salience (SN), executive control, and default mode networks has been suggested to be critical for efficient cognition. Here, we aimed to test the hypothesis that SN may play a role in cognitive impairment in patients with ESRD.

Materials and methods

We investigated functional connectivity (FC) alterations within the SN between 43 ESRD patients (19 females/24 males, 46 ± 10 years) and 43 healthy controls (HC) (19 females/24 males, 47 ± 10 years), and performed linear support vector machine (LSVM) analysis on significant FC pairs within the SN to discriminate the two groups, and tested the accuracy of the classifier. Association and me

SUBMITTER: Hu R 

PROVIDER: S-EPMC7693456 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature