Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function.

ABSTRACT:

Background

Tetraspanins are a family of proteins known to assemble protein complexes at the cell membrane. They are thought to play diverse cellular functions in tissues by modifying protein-binding partners, thus bringing complexity and diversity in their regulatory networks. Previously, we identified the tetraspanin KAI/CD82 as a prospective marker for human muscle stem cells. CD82 expression appeared decreased in human Duchenne muscular dystrophy (DMD) muscle, suggesting a functional link to muscular dystrophy, yet whether this decrease is a consequence of dystrophic pathology or a compensatory mechanism in an attempt to rescue muscle from degeneration is currently unknown.

Methods

We studied the consequences of loss of CD82 expression in normal and dystrophic skeletal mu

SUBMITTER: Hall A 

PROVIDER: S-EPMC7693590 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature