Impact of Genetic Ancestry on Prognostic Biomarkers in Uveal Melanoma.

ABSTRACT: Uveal melanoma (UM) is the most common cancer of the eye and leads to metastatic death in up to half of patients. Genomic prognostic biomarkers play an important role in clinical management in UM. However, research has been conducted almost exclusively in patients of European descent, such that the association between genetic admixture and prognostic biomarkers is unknown. In this study, we compiled 1381 control genomes from West African, European, East Asian, and Native American individuals, assembled a bioinformatic pipeline for assessing global and local ancestry, and performed an initial pilot study of 141 UM patients from our international referral center that manages many admixed individuals. Global and local estimates were associated with genomic prognostic determinants. Expression

SUBMITTER: Rodriguez DA 

PROVIDER: S-EPMC7693692 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature