Integrative Computational Approach Revealed Crucial Genes Associated With Different Stages of Diabetic Retinopathy.

ABSTRACT: The increased incidence of diabetic retinopathy (DR) and the legacy effect associated with it has raised a great concern toward the need to find early diagnostic and treatment strategies. Identifying alterations in genes and microRNAs (miRNAs) is one of the most critical steps toward understanding the mechanisms by which a disease progresses, and this can be further used in finding potential diagnostic and prognostic biomarkers and treatment methods. We selected different datasets to identify altered genes and miRNAs. The integrative analysis was employed to find potential candidate genes (differentially expressed and aberrantly methylated genes that are also the target of altered miRNAs) and early genes (genes showing altered expression and methylation pattern during early stage of DR) fo

SUBMITTER: Kumari N 

PROVIDER: S-EPMC7693709 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature