Temozolomide Treatment Increases Fatty Acid Uptake in Glioblastoma Stem Cells.

ABSTRACT: Among all cancers, glioblastoma (GBM) remains one of the least treatable. One key factor in this resistance is a subpopulation of tumor cells termed glioma stem cells (GSCs). These cells are highly resistant to current treatment modalities, possess marked self-renewal capacity, and are considered key drivers of tumor recurrence. Further complicating an understanding of GBM, evidence shows that the GSC population is not a pre-ordained and static group of cells but also includes previously differentiated GBM cells that have attained a GSC state secondary to environmental cues. The metabolic behavior of GBM cells undergoing plasticity remains incompletely understood. To that end, we probed the connection between GSCs, environmental cues, and metabolism. Using patient-derived xenograft cells,

SUBMITTER: Caragher S 

PROVIDER: S-EPMC7693784 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature