COVID-19 and Parkinson's Disease: Shared Inflammatory Pathways Under Oxidative Stress.

ABSTRACT: The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson's disease (PD). Increasing evidence suggests an involvement of oxidative stress and contribution of NFκB in the development of both COVID-19 and PD. Although, it is early to identify if SARS-CoV-2 led infection enhances PD complications, it is likely that oxidative stress may exacerbate PD progression in COVID-19 affected individuals and/or vice versa. In the current study, we sought to investigate whether NFκB-associated inflammatory pathways following oxidative stress in SARS-CoV-2 and PD patients are correlated. Toward this goal, we have integrated

SUBMITTER: Chaudhry ZL 

PROVIDER: S-EPMC7693814 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature