Novel Electrospun Pullulan Fibers Incorporating Hydroxypropyl-β-Cyclodextrin: Morphology and Relation with Rheological Properties.

ABSTRACT: Fibers produced by electrospinning from biocompatible, biodegradable and naturally occurring polymers have potential advantages in drug delivery and biomedical applications because of their unique functionalities. Here, electrospun submicron fibers were produced from mixtures containing an exopolysaccharide (pullulan) and a small molecule with hosting abilities, hydroxypropyl-β-cyclodextrin (HP-β-CD), thus serving as multi-functional blend. The procedure used water as sole solvent and excluded synthetic polymers. Rheological characterization was performed to evaluate the impact of HP-β-CD on pullulan entanglement concentration (C_E); the relationship with electrospinnability and fiber morphology was investigated. Neat pullulan solutions required three times C_E (~20% w/

SUBMITTER: Poudel D 

PROVIDER: S-EPMC7693914 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature