The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis.

ABSTRACT: Epstein-Barr-virus-associated Gastric Cancer (EBVaGC) comprises approximately 10% of global gastric cancers and is known to be the most hypermethylated of all tumor types. EBV infection has been shown to directly induce the hypermethylation of both the host and viral genome following initial infection of gastric epithelial cells. Many studies have been completed in an attempt to identify genes that frequently become hypermethylated and therefore significant pathways that become silenced to promote tumorigenesis. It is clear that EBV-induced hypermethylation silences key tumor suppressor genes, cell cycle genes and cellular differentiation factors to promote a highly proliferative and poorly differentiated cell population. EBV infection has been shown to induce methylation in additional mal

SUBMITTER: Stanland LJ 

PROVIDER: S-EPMC7693998 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature