The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies.

ABSTRACT: Tremendous progress in RNAi delivery methods and design has allowed for the effective development of siRNA-based therapeutics that are currently under clinical investigation for various cancer treatments. This approach has the potential to revolutionize cancer therapy by providing the ability to specifically downregulate or upregulate the mRNA of any protein of interest. This exquisite specificity, unfortunately, also has a downside. Genetic variations in the human population are common because of the presence of single nucleotide polymorphisms (SNPs). SNPs lead to synonymous and non-synonymous changes and they occur once in every 300 base pairs in both coding and non-coding regions in the human genome. Much less common are the somatic mosaicism variations associated with genetically disti

SUBMITTER: Gebert M 

PROVIDER: S-EPMC7694039 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature