Impact of PET/CT for Assessing Response to Immunotherapy-A Clinical Perspective.

ABSTRACT: Cancer immunotherapy using immune-checkpoint inhibitors (ICI) has revolutionized the therapeutic landscape of various malignancies like non-small-cell lung cancer or melanoma. Pre-therapy response prediction and assessment during ICI treatment is challenging due to the lack of reliable biomarkers and the possibility of atypical radiological response patterns. Positron emission tomography/computed tomography (PET/CT) enables the visualization and quantification of metabolic lesion activity additional to conventional CT imaging. Various biomarkers derived from PET/CT have been reported as predictors for response to ICI and may aid to overcome the challenges clinicians currently face in the management of ICI-treated patients. In this narrative review, experts in nuclear medicine, thoracic onc

SUBMITTER: Lang D 

PROVIDER: S-EPMC7694130 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature