Cardiac and Vascular α₁-Adrenoceptors in Congestive Heart Failure: A Systematic Review.

ABSTRACT: As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular α₁-ARs in HF using 5 databases for our search. All three α₁-AR subtypes (α_1A, α_1B and α_1D) are expressed in human and animal hearts and blood ve

SUBMITTER: Kaykı-Mutlu G 

PROVIDER: S-EPMC7694190 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature