Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells.

ABSTRACT: Cancer stem cells (CSCs) have both the capacity for self-renewal and the potential to differentiate and contribute to multiple tumor properties, such as recurrence, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Thus, CSCs are considered to be promising therapeutic targets for cancer therapy. The function of CSCs can be regulated by ubiquitination and deubiquitination of proteins related to the specific stemness of the cells executing various stem cell fate choices. To regulate the balance between ubiquitination and deubiquitination processes, the disassembly of ubiquitin chains from specific substrates by deubiquitinating enzymes (DUBs) is crucial. Several key developmental and signaling pathways have been shown to play essential roles in this regulation. Growi

SUBMITTER: Kaushal K 

PROVIDER: S-EPMC7694198 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature