An Overview of Astrocyte Responses in Genetically Induced Alzheimer's Disease Mouse Models.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia. Despite many years of intense research, there is currently still no effective treatment. Multiple cell types contribute to disease pathogenesis, with an increasing body of data pointing to the active participation of astrocytes. Astrocytes play a pivotal role in the physiology and metabolic functions of neurons and other cells in the central nervous system. Because of their interactions with other cell types, astrocyte functions must be understood in their biologic context, thus many studies have used mouse models, of which there are over 190 available for AD research. However, none appear able to fully recapitulate the many functional changes in astrocytes reported in human AD brains. Our review summarizes the observations of a

SUBMITTER: Spanos F 

PROVIDER: S-EPMC7694249 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature