DPM1 expression as a potential prognostic tumor marker in hepatocellular carcinoma.

ABSTRACT:

Background

Altered glycosylation of proteins contributes to tumor progression. Dolichol phosphate mannose synthase (DPMS), an essential mannosyltransferase, plays a central role in post-translational modification of proteins, including N-linked glycoproteins, O-mannosylation, C-mannosylation and glycosylphosphatidylinositol anchors synthesis. Little is known about the function of DPMS in liver cancer.

Methods

The study explored the roles of DPMS in the prognosis of hepatocellular carcinoma using UALCAN, Human Protein Atlas, GEPIA, cBioPortal and Metascape databases. The mRNA expressions of DPM1/2/3 also were detected by quantitative real-time PCR experiments in vitro.

Results

The transcriptional and proteinic expressions of DPM1/2/3 were both over-expressed in patient

SUBMITTER: Li M 

PROVIDER: S-EPMC7694566 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature