Toxicological Characterization and Phospholipase D Activity of the Venom of the Spider Sicarius thomisoides.

ABSTRACT: Envenomation by Loxosceles spiders (Sicariidae family) has been thoroughly documented. However, little is known about the potential toxicity of members from the Sicarius genus. Only the venom of the Brazilian Sicarius ornatus spider has been toxicologically characterized. In Chile, the Sicarius thomisoides species is widely distributed in desert and semidesert environments, and it is not considered a dangerous spider for humans. This study aimed to characterize the potential toxicity of the Chilean S. thomisoides spider. To do so, specimens of S. thomisoides were captured in the Atacama Desert, the venom was extracted, and the protein concentration was determined. Additionally, the venoms were analyzed by electrophoresis and Western blotting using anti-recombinant L. laeta PLD1 serum. Phos

SUBMITTER: Aran-Sekul T 

PROVIDER: S-EPMC7694614 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature