Can Polyphenols in Eye Drops Be Useful for Trabecular Protection from Oxidative Damage?

ABSTRACT: Polyphenols, with anti-oxidant properties, counteract oxidative stress effects. Increasing evidence has found oxidative stressto be the main risk factor for trabecular meshwork (TM) damage, leading to high-tension glaucoma. Topical anti-oxidants could represent a new target for glaucoma treatment. Our aim is to investigate the protective mechanisms on a human TM culture of a patented polyphenol and fatty acid (iTRAB^®)formulation in response to oxidative stress using an advanced invitromodel consisting of 3D-human TM cells, embedded in a natural hydrogel, and a milli-scaled multi-organ device model for constantdynamic conditions. The 3D-human TM cells(3D-HTMCs) were treated daily with 500 µM H₂O₂or 500 µM H₂O₂and 0.15% iTRAB^®

SUBMITTER: Sacca SC 

PROVIDER: S-EPMC7694784 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature