Current and emerging concepts in biological and analytical variation applied in clinical practice.

ABSTRACT: A single laboratory result actually represents a range of possible values, and a given laboratory result is impacted not just by the presence or absence of disease, but also by biological variation of the measurand in question and analytical variation of the equipment used to make the measurement. Biological variation refers to variability in measurand concentration or activity around a homeostatic set point. Knowledge of biological and analytical variation can be used to facilitate interpretation of patient clinicopathologic data and is particularly useful for interpreting serial patient data and data at or near reference limits or clinical decision thresholds. Understanding how biological and analytical variation impact laboratory results is of increasing importance, because veterinarian

SUBMITTER: Flatland B 

PROVIDER: S-EPMC7694803 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature